Testosterone + Advanced Male Hormone Blood Panel (Male Only)

This blood test is ideal for men who would like a comprehensive understanding of their testosterone levels and how it relates to other key hormones. Recommended for those considering testosterone replacement therapy.

Blood panel includes the following results:

Free and bioavailable testosterone: Most of the testosterone in blood attaches to two proteins- albumin (30-40%) and sex hormone- binding globulin.(SHBG -65%) The remaining testosterone, approximate 1-2% that is not attached to anything is the free testosterone. Bioavailable testosterone is a measure of free testosterone combined with testosterone bound to albumin.

The bio-available testosterone plays a key role because it is the level that the body has available for use to enter a cell and activate the receptor. When testosterone is bound to SHBG, it can’t jump off and do its job on the target tissue.

Estradiol: One of the hormones in the group commonly referred to as estrogens. In males, estradiol is involved in sperm maturation and also helps to maintain a healthy libido.

High levels of testosterone are converted into estradiol in men. While estradiol has a significant role in maintaining healthy bone growth and improving blood flow in coronary arteries in addition to offering neuroprotective effects, high estradiol levels in men can result in weight gain, fatigue, erectile dysfunction, increased chest and belly fat, hot flashes, night sweats & excessive urination.

DHEA-S: DHEA is produced by the adrenal glands and is a precursor to both testosterone and estrogens. In men, low DHEA levels can cause low libido, reduced muscle mass and strength, depression, fatigue and compromised immune function.

FSH (Follicle Stimulating Hormone): FSH levels can be helpful in the diagnosis of hypogonadism ( male sex hormone deficiency). If the FSH levels are raised, this can suggests a primary testicular cause, and if levels are low or normal, a hypothalamic or pituitary (brain) cause should be considered. In men, FSH stimulates the testes to produce mature sperm and also promotes the production of androgen binding proteins. FSH levels are relatively constant in males after puberty.

LH (Luteinizing hormone): LH is produced by the pituitary gland located in the brain. LH levels can be helpful in the diagnosis of hypogonadism (male sex hormone deficiency ). If the LH levels are high, this can suggest a primary testicular cause, and if the levels are low or normal, a pituitary (brain) cause should be considered. Testosterone provides negative feedback to the pituitary and the hypothalamus, helping to regulate the amount of LH secreted.

SHBG = SHBG-bound testosterone – Sex hormone-binding globulin (SHBG) is a protein made by your liver and is found in both men and women. It binds tightly to three hormones: estrogen; dihydrotestosterone (DHT), and testosterone. SHBG is responsible for carrying these three hormones throughout your blood. SHBG controls the amount of testosterone that your body tissues can use, and approximately 65% the of the testosterone is bound to SHBG. Albumin, another protein binds approximately 30-40% of testosterone in the blood. Only about 1-2% of testosterone is unbound or free and thus biologically available to enter a cell and activate the receptor. SHBG therefore inhibits the function of testosterone in the blood by binding tightly to it.

Too little testosterone in men and too much testosterone in women can cause problems. The level of SHBG in your blood changes because of factors such as sex and age. It can also change because of obesity, liver disease, and hyperthyroidism.

Low levels of SHBG can be related to obesity, Type 2 diabetes, hypothyroidism, acromegly. High levels of SHBG can be related to hepatitis, hyperthyroidism, HIV and anticonvulsants or other medicines used to treat seizures.